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WEIGHT DISBALANCE

Accumulating research studies are suspecting the gut microbiome to be one of the biggest players involved in the development of certain metabolic syndromes. Some studies demonstrate that diet and lifestyle change the composition and activity of the gut microbiome. Animal studies and human trials have shown that a characteristic element of the obese phenotype are modifications of the microbiome towards increased energy harvest. Another parameter that contrasts the microbiome of lean versus obese individuals is the fermentable ability of the gut community. This ability is based on the non-digestible dietary components introduced with the food intake, important in short-chain fatty acid (SCFA) generation by the microbiome. These SCFA molecules promote energy storage within the host. Animal studies showed that transplantation of the gut microbiota from obese mice to germ free donors resulted in a significant rise in total body fat, demonstrating that the gut microbiome is largely involved in maintaining a certain weight.

    Luckily there is bactoyou, offering a solution to your weight disbalance. By re-introducing a past captured microbiome, a bac-up, you can make sure to maintain the gut make-up of a lean individual.

Sonnenburg, Justin L., and Fredrik Bäckhed. "Diet–microbiota Interactions as Moderators of Human Metabolism." Nature 535, no. 7610 (2016): 56-64. doi:10.1038/nature18846.

Jandhyala, Sai Manasa. "Role of the Normal Gut Microbiota." World Journal of Gastroenterology 21, no. 29 (2015): 8787. doi:10.3748/wjg.v21.i29.8787.

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David LA, Maurice CF, Carmody RN, Gootenberg DB, Button JE, Wolfe BE, Ling AV, Devlin AS, Varma Y, Fischbach MA, et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 2014;505(7484):559–563. doi: 10.1038/nature12820.

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den Besten G, van Eunen K, Groen AK, Venema K, Reijngoud DJ, Bakker BM. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. J Lipid Res. 2013;54(9):2325–2340. doi: 10.1194/jlr.R036012.

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Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006;444(7122):1027–1031. doi: 10.1038/nature05414.

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